Advances of peptides for antibacterial applications

Y Yan, Y Li, Z Zhang, X Wang, Y Niu, S Zhang… - Colloids and Surfaces B …, 2021 - Elsevier
In the past few decades, peptide antibacterial products with unique antibacterial
mechanisms have attracted widespread interest. They can effectively reduce the probability …

[HTML][HTML] The human cathelicidin LL-37—A pore-forming antibacterial peptide and host-cell modulator

D Xhindoli, S Pacor, M Benincasa, M Scocchi… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …

Human antimicrobial peptides and proteins

G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Host defense antimicrobial peptides as antibiotics: design and application strategies

B Mishra, S Reiling, D Zarena, G Wang - Current opinion in chemical …, 2017 - Elsevier
Highlights•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are
important templates for develo** new antibiotics.•Both peptide discovery and application …

Design of antimicrobial peptides: progress made with human cathelicidin LL-37

G Wang, JL Narayana, B Mishra, Y Zhang… - … Peptides: Basics for …, 2019 - Springer
The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases

A Zecconi, F Scali - Immunology letters, 2013 - Elsevier
In the last decades, Staphylococcus aureus acquired a dramatic relevance in human and
veterinary medicine for different reasons, one of them represented by the increasing …

Antimicrobial peptides in 2014

G Wang, B Mishra, K Lau, T Lushnikova, R Golla… - Pharmaceuticals, 2015 - mdpi.com
This article highlights new members, novel mechanisms of action, new functions, and
interesting applications of antimicrobial peptides reported in 2014. As of December 2014 …

The Pathogenesis of Staphylococcus aureus Eye Infections

RJ O'Callaghan - Pathogens, 2018 - mdpi.com
Staphylococcus aureus is a major pathogen of the eye able to infect the tear duct, eyelid,
conjunctiva, cornea, anterior and posterior chambers, and the vitreous chamber. Of these …

[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

G Wang, B Mishra, RF Epand, RM Epand - Biochimica et Biophysica Acta …, 2014 - Elsevier
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …

Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability

S Gunasekera, T Muhammad, AA Strömstedt… - Frontiers in …, 2020 - frontiersin.org
Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by
making them into dimers and macrocycles? Here, we explore that concept by using KR-12 …