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Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Protective neutralizing epitopes in SARS‐CoV‐2
H Liu, IA Wilson - Immunological reviews, 2022 - Wiley Online Library
The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …
In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus
Seasonal human influenza is a serious respiratory infection caused by influenza viruses that
can be found all over the world. Type A influenza is a contagious viral infection that, if left …
can be found all over the world. Type A influenza is a contagious viral infection that, if left …
Fluorescence polarization-based bioassays: New horizons
OD Hendrickson, NA Taranova, AV Zherdev… - Sensors, 2020 - mdpi.com
Fluorescence polarization holds considerable promise for bioanalytical systems because it
allows the detection of selective interactions in real time and a choice of fluorophores, the …
allows the detection of selective interactions in real time and a choice of fluorophores, the …
Design of tracers in fluorescence polarization assay for extensive application in small molecule drug discovery
L Hua, D Wang, K Wang, Y Wang, J Gu… - Journal of Medicinal …, 2023 - ACS Publications
Development of fluorescence polarization (FP) assays, especially in a competitive manner,
is a potent and mature tool for measuring the binding affinities of small molecules. This …
is a potent and mature tool for measuring the binding affinities of small molecules. This …
Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry
Seasonal and pandemic-associated influenza strains cause highly contagious viral
respiratory infections that can lead to severe illness and excess mortality. Here, we report on …
respiratory infections that can lead to severe illness and excess mortality. Here, we report on …
Neutralizing antibodies to block viral entry and for identification of entry inhibitors
EH Tam, Y Peng, MXY Cheah, C Yan, T **ao - Antiviral Research, 2024 - Elsevier
Neutralizing antibodies (NAbs) are naturally produced by our immune system to combat viral
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …
[HTML][HTML] Structural biology of influenza hemagglutinin: An amaranthine adventure
NC Wu, IA Wilson - Viruses, 2020 - mdpi.com
Hemagglutinin (HA) glycoprotein is an important focus of influenza research due to its role in
antigenic drift and shift, as well as its receptor binding and membrane fusion functions …
antigenic drift and shift, as well as its receptor binding and membrane fusion functions …
pH-dependent mechanisms of influenza infection mediated by hemagglutinin
M Caffrey, A Lavie - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Influenza hemagglutinin (HA) is a viral membrane bound protein that plays a critical role in
the viral life cycle by mediating entry into target cells. HA exploits the lowering of the pH in …
the viral life cycle by mediating entry into target cells. HA exploits the lowering of the pH in …
[HTML][HTML] Small molecule inhibitors of influenza virus entry
Z Chen, Q Cui, M Caffrey, L Rong, R Du - Pharmaceuticals, 2021 - mdpi.com
Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and
subsequent membrane fusion process, thus HA has become a promising drug target. For the …
subsequent membrane fusion process, thus HA has become a promising drug target. For the …