Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies
J Zhang, Y Zhang, J Wang, Y ** noncovalent small molecules targeting Keap1
Highlights•The Keap1-Nrf2 interaction is a major regulator of antioxidant and
antiinflammatory proteins.•Keap1-Nrf2 inhibitors activate Nrf2 leading to cytoprotection.• …
antiinflammatory proteins.•Keap1-Nrf2 inhibitors activate Nrf2 leading to cytoprotection.• …
An updated patent review of Nrf2 activators (2020-present)
Z Zhao, R Dong, K Cui, Q You… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription
factor that controls the expression of numerous cytoprotective genes and regulates cellular …
factor that controls the expression of numerous cytoprotective genes and regulates cellular …
Methyl and fluorine effects in novel orally bioavailable keap1–Nrf2 PPI inhibitor
K Otake, M Ubukata, N Nagahashi… - ACS Medicinal …, 2023 - ACS Publications
Oxidative stress is one of the causes of progression of chronic kidney disease (CKD).
Activation of the antioxidant protein regulator Nrf2 by inhibition of the Keap1–Nrf2 protein …
Activation of the antioxidant protein regulator Nrf2 by inhibition of the Keap1–Nrf2 protein …
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction
The disruption of the protein–protein interaction (PPI) between Nrf2 and Keap1 is an
attractive strategy to counteract the oxidative stress that characterises a variety of severe …
attractive strategy to counteract the oxidative stress that characterises a variety of severe …
Structural modification of C2-substituents on 1, 4-bis (arylsulfonamido) benzene or naphthalene-N, N′-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 …
Abstract The Keap1-Nrf2-ARE signaling pathway is an attractive therapeutic target for the
prevention and treatment of oxidative stress-associated diseases by activating the cellular …
prevention and treatment of oxidative stress-associated diseases by activating the cellular …
The role of organosulfur compounds as Nrf2 activators and their antioxidant effects
Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling has become a key pathway for
cellular regulation against oxidative stress and inflammation, and therefore an attractive …
cellular regulation against oxidative stress and inflammation, and therefore an attractive …