Development, wiring and function of dopamine neuron subtypes
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …
Transcriptomic diversity of cell types across the adult human brain
The human brain directs complex behaviors, ranging from fine motor skills to abstract
intelligence, but the diversity of cell types that support these skills has not been fully …
intelligence, but the diversity of cell types that support these skills has not been fully …
Neurotensin and energy balance
The neurotensin system spans across the central nervous system, to the enteric nervous
system (gut), and the periphery to govern behaviors and physiological responses that tune …
system (gut), and the periphery to govern behaviors and physiological responses that tune …
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition
The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
Overlap** representations of food and social stimuli in mouse VTA dopamine neurons
Dopamine neurons of the ventral tegmental area (VTA DA) respond to food and social
stimuli and contribute to both forms of motivation. However, it is unclear whether the same or …
stimuli and contribute to both forms of motivation. However, it is unclear whether the same or …
Brain-wide correspondence of neuronal epigenomics and distant projections
Single-cell analyses parse the brain's billions of neurons into thousands of 'cell-type'clusters
residing in different brain structures. Many cell types mediate their functions through targeted …
residing in different brain structures. Many cell types mediate their functions through targeted …
Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice
Initiating drug use during adolescence increases the risk of develo** addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …
psychopathologies later in life, with long-term outcomes varying according to sex and exact …
Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder
Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and
addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei …
addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei …
Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights
Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …
compulsive overconsumption of rewarding substances such as substance abuse, binge …
[HTML][HTML] Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology
As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …
neuroscientists studying a wide gamut of brain regions have discovered remarkable …