Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …

Dense and aligned Collagen I fibers are associated with collective cancer invasion led by
protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells …

Embryonic induction is a key mechanism in development that corresponds to an interaction
between a signalling and a responding tissue, causing a change in the direction of …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is
regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in …

Therapeutic resistance and metastasis largely contribute to mortality from breast cancer and
therefore understanding the underlying mechanisms of such remains an urgent challenge …

ABSTRACT H. pylori infection is the strongest known risk factor for gastric carcinoma. The
activation of the yes-associated protein 1 (YAP) and β-catenin pathways has been …

Lung cancer is the second most frequently diagnosed cancer worldwide and a leading
cause of cancer-related deaths. Non-small cell lung carcinoma (NSCLC) represents 85% of …

As a devastating disease, breast cancer has been responsible for decrease in life
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …