Paracrine mechanisms in adult stem cell signaling and therapy

M Gnecchi, Z Zhang, A Ni, VJ Dzau - Circulation research, 2008 - Am Heart Assoc
Animal and preliminary human studies of adult cell therapy following acute myocardial
infarction have shown an overall improvement of cardiac function. Myocardial and vascular …

Estrogen and the cardiovascular system

AA Knowlton, AR Lee - Pharmacology & therapeutics, 2012 - Elsevier
Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities

TM Paravicini, RM Touyz - Diabetes care, 2008 - Am Diabetes Assoc
Reactive oxygen species (ROS) influence many physiological processes including host
defense, hormone biosynthesis, fertilization, and cellular signaling. Increased ROS …

Heme oxygenases in cardiovascular health and disease

A Ayer, A Zarjou, A Agarwal… - Physiological …, 2016 - journals.physiology.org
Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Restenosis after PCI. Part 1: pathophysiology and risk factors

JW Jukema, JJW Verschuren, TAN Ahmed… - Nature Reviews …, 2012 - nature.com
Restenosis is a complex disease for which the pathophysiological mechanisms have not yet
been fully elucidated, but are thought to include inflammation, proliferation, and matrix …

Endothelial progenitor cell capture by stents coated with antibody against CD34: the HEALING-FIM (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth …

J Aoki, PW Serruys, H van Beusekom, ATL Ong… - Journal of the American …, 2005 - jacc.org
Objectives: This study was designed to evaluate whether rapid endothelialization of
stainless steel stents with a functional endothelium prevents stent thrombosis and reduces …

Vascular repair by endothelial progenitor cells

A Zampetaki, JP Kirton, Q Xu - Cardiovascular research, 2008 - academic.oup.com
Accumulating evidence indicates the impact of endothelial progenitor cells (EPCs) in
vascular repair. In patients, the number of EPCs is negatively correlated with the severity of …

Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

Z Yang, X Zhao, R Hao, Q Tu, X Tian… - Proceedings of the …, 2020 - National Acad Sciences
Thrombogenic reaction, aggressive smooth muscle cell (SMC) proliferation, and sluggish
endothelial cell (EC) migration onto bioinert metal vascular stents make poststenting …

Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance

M Hristov, C Weber - Journal of cellular and molecular …, 2004 - Wiley Online Library
Bone marrow and peripheral blood of adults contain a special sub‐type of progenitor cells
which are able to differentiate into mature endothelial cells, thus contributing to re …

Angiogenesis: where do we stand now?

M Simons - Circulation, 2005 - Am Heart Assoc
The role of preexisting collateral channels in the heart is far less well established. Early
studies failed to show the existence of coronary-to-coronary artery connection in normal …