Numerous bacteria utilize molecular communication systems referred to as quorum sensing
(QS) to synchronize the expression of certain genes regulating, among other aspects, the …

Detection of foreign nucleic acids is an important strategy for innate immune recognition of
pathogens. In vertebrates, pathogen-derived DNA is sensed in the cytosol by cGAS, which …

Aging clocks dissociate biological from chronological age. The estimation of biological age
is important for identifying gerontogenes and assessing environmental, nutritional, or …

Impairment of ribosome function activates the MAPKKK ZAK, leading to activation of mitogen-
activated protein (MAP) kinases p38 and JNK and inflammatory signaling. The mechanistic …

DNA damage plays a causal role in numerous human pathologies including cancer,
premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …

Numerous approaches have been taken in the hunt for human disease genes. The
identification of such genes not only provides a great deal of information about the …