Chagas disease: an overview of clinical and epidemiological aspects

MCP Nunes, W Dones, CA Morillo, JJ Encina… - Journal of the American …, 2013 - jacc.org
Chagas disease, caused by the parasite Trypanosoma cruzi, is a serious health problem in
Latin America and is an emerging disease in non-endemic countries. In recent decades, the …

Chagas disease cardiomyopathy: immunopathology and genetics

E Cunha-Neto, C Chevillard - Mediators of inflammation, 2014 - Wiley Online Library
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America
and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop …

The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

C Junqueira, B Caetano, DC Bartholomeu… - Expert reviews in …, 2010 - cambridge.org
Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …

Chemokines, inflammation and Trypanosoma cruzi infection

MM Teixeira, RT Gazzinelli, JS Silva - Trends in parasitology, 2002 - cell.com
The inflammatory response that follows the infection with Trypanosoma cruzi is essential for
host resistance to infection but is also responsible for the diverse pathology observed in …

[HTML][HTML] Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead

KM Bonney, DM Engman - The American journal of pathology, 2015 - Elsevier
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of individuals infected with the protozoan parasite Trypanosoma cruzi. Since the …

Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy

C Chevillard, JPS Nunes, AF Frade… - Frontiers in …, 2018 - frontiersin.org
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …

Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10

LG Nogueira, RHB Santos, BM Ianni… - PLoS Neglected …, 2012 - journals.plos.org
Background Chronic Chagas cardiomyopathy (CCC), a life-threatening inflammatory dilated
cardiomyopathy, affects 30% of the approximately 8 million patients infected by …

Cytokine networks as targets for preventing and controlling Chagas heart disease

CC Koh, EGA Neves, TG de Souza-Silva, AC Carvalho… - Pathogens, 2023 - mdpi.com
Chagas disease, a neglected disease caused by the protozoan Trypanosoma cruzi, is
endemic in 21 Latin American countries, affecting 6–8 million people. Increasing numbers of …

CCR5 Plays a Critical Role in the Development of Myocarditis and Host Protection in Mice Infected with Trypanosoma cruzi

FS Machado, NS Koyama, V Carregaro… - The Journal of …, 2005 - academic.oup.com
The pathogenesis of myocarditis during Trypanosoma cruzi infection is poorly understood.
We investigated the role played by chemokine receptor 5 (CCR5) in the influx of T cells to …

The determinants of Chagas disease: connecting parasite and host genetics

DA Campbell, SJ Westenberger… - Current molecular …, 2004 - ingentaconnect.com
As a consequence of infection by Trypanosoma cruzi, 30% of victims may develop chronic
Chagas disease, which presents a spectrum of pathology including cardiomyopathy …