Recent advances in cryo-electron microscopy have marked only the beginning of the
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …

Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with
over 370 structures in total bound to different ligands and the receptors in various …

Parkinson's disease (PD) is the most common movement disorder, with resting tremor,
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage. The receptor …

Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis
downstream of inflammasome activation and was previously shown to form large …

Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …

Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …

There is considerable interest in screening ultralarge chemical libraries for ligand discovery,
both empirically and computationally,,–. Efforts have focused on readily synthesizable …

Macromolecular structure determination by electron cryo-microscopy (cryo-EM) is limited by
the alignment of noisy images of individual particles. Because smaller particles have weaker …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern evades antibody-mediated immunity that comes from vaccination or infection with …