Sulfhydryl groups as targets of mercury toxicity

OP Ajsuvakova, AA Tinkov, M Aschner… - Coordination chemistry …, 2020‏ - Elsevier
The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …

Association between heavy metal exposure and Parkinson's disease: a review of the mechanisms related to oxidative stress

S Pyatha, H Kim, D Lee, K Kim - Antioxidants, 2022‏ - mdpi.com
Parkinson's disease (PD) is a gradually progressing neurodegenerative condition that is
marked by a loss of motor coordination along with non-motor features. Although the precise …

The toxicology of mercury: Current research and emerging trends

G Bjørklund, M Dadar, J Mutter, J Aaseth - Environmental research, 2017‏ - Elsevier
Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical
properties of public health concern since their natural and anthropogenic diffusions still …

Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury

M Farina, DS Avila, JBT Da Rocha… - Neurochemistry …, 2013‏ - Elsevier
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …

Environmental toxins and Parkinson's disease

SM Goldman - Annual review of pharmacology and toxicology, 2014‏ - annualreviews.org
Parkinson's disease (PD) is a chronic, progressive, disabling neurodegenerative disorder
that begins in mid to late life and is characterized by motor impairment, autonomic …

Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands

K Pugsley, SW Scherer, MA Bellgrove, Z Hawi - Molecular psychiatry, 2022‏ - nature.com
Although the full aetiology of autism spectrum disorder (ASD) is unknown, familial and twin
studies demonstrate high heritability of 60–90%, indicating a predominant role of genetics in …

Ferroptosis as a mechanism of non-ferrous metal toxicity

M Aschner, AV Skalny, AC Martins, AI Sinitskii… - Archives of …, 2022‏ - Springer
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple
pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron …

The toxicology of mercury and its compounds

T Syversen, P Kaur - Journal of Trace Elements in Medicine and Biology, 2012‏ - Elsevier
A concentrated review on the toxicology of inorganic mercury together with an extensive
review on the neurotoxicology of methylmercury is presented. The challenges of using …

Gliotransmitter release from astrocytes: functional, developmental, and pathological implications in the brain

K Harada, T Kamiya, T Tsuboi - Frontiers in neuroscience, 2016‏ - frontiersin.org
Astrocytes comprise a large population of cells in the brain and are important partners to
neighboring neurons, vascular cells, and other glial cells. Astrocytes not only form a scaffold …

Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies

M Farina, JBT Rocha, M Aschner - Life sciences, 2011‏ - Elsevier
Neurological disorders are common, costly, and can cause enduring disability. Although
mostly unknown, a few environmental toxicants are recognized causes of neurological …