Lipid droplet nucleation
All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets,
surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid …
surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid …
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis
Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis
LPCAT3 is an integral membrane acyltransferase in the Lands cycle responsible for
generating C20: 4 phospholipids and has been implicated in key biological processes such …
generating C20: 4 phospholipids and has been implicated in key biological processes such …
Mechanisms and inhibition of Porcupine-mediated Wnt acylation
Wnt signalling is essential for regulation of embryonic development and adult tissue
homeostasis,–, and aberrant Wnt signalling is frequently associated with cancers. Wnt …
homeostasis,–, and aberrant Wnt signalling is frequently associated with cancers. Wnt …
The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3
Q Zhang, D Yao, B Rao, L Jian, Y Chen, K Hu… - Nature …, 2021 - nature.com
As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de
novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation …
novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation …
Lipodistrophy: a paradigm for understanding the consequences of “overloading” adipose tissue
K Lim, A Haider, C Adams, A Sleigh… - Physiological …, 2021 - journals.physiology.org
Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …
their rarity, tended to attract considerable medical attention because of the severity and …
The uniqueness of clear cell renal cell carcinoma: summary of the process and abnormality of glucose metabolism and lipid metabolism in ccRCC
X Qi, Q Li, X Che, Q Wang, G Wu - Frontiers in Oncology, 2021 - frontiersin.org
Kidney cancer is a cancer with an increasing incidence in recent years. Clear cell renal cell
carcinoma (ccRCC) accounts for up to 80% of all kidney cancers. The understanding of the …
carcinoma (ccRCC) accounts for up to 80% of all kidney cancers. The understanding of the …
Non-contaminating cryogenic fluid access to high-temperature resources: Liquid nitrogen fracturing in a lab-scale Enhanced Geothermal System
Hot dry rock (HDR) geothermal energy exploitation is essential to meet the energy demand
and achieve low-carbon solutions. Creation of complex fracture networks in HDR by …
and achieve low-carbon solutions. Creation of complex fracture networks in HDR by …
The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification
Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane
properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso …
properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso …