[HTML][HTML] Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

M Sultan, R Arya, KK Kim - International journal of molecular sciences, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a
wide range of virulence factors. P. aeruginosa poses a potential threat to human health …

Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

T De Sousa, M Hébraud, MLNE Dapkevicius… - International journal of …, 2021 - mdpi.com
In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas
aeruginosa infections has gradually decreased. This pathogen can be observed in several …

Two-component systems required for virulence in Pseudomonas aeruginosa

VI Francis, EC Stevenson, SL Porter - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

[HTML][HTML] Two component regulatory systems and antibiotic resistance in Gram-negative pathogens

AY Bhagirath, Y Li, R Patidar, K Yerex, X Ma… - International journal of …, 2019 - mdpi.com
Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …

Environmental adaptation and diversification of bacterial two-component systems

AF Alvarez, D Georgellis - Current Opinion in Microbiology, 2023 - Elsevier
Bacterial two-component systems (TCS) are versatile signaling mechanisms that govern
cellular responses to diverse environmental cues. These systems rely on phosphoryl-group …

[HTML][HTML] Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors

H Song, Y Li, Y Wang - Engineering Microbiology, 2023 - Elsevier
The signal transduction system of microorganisms helps them adapt to changes in their
complex living environment. Two-component system (TCS) is a representative signal …

Surface Sensing for Biofilm Formation in Pseudomonas aeruginosa

CY Chang - Frontiers in microbiology, 2018 - frontiersin.org
Aggregating and forming biofilms on biotic or abiotic surfaces are ubiquitous bacterial
behaviors under various conditions. In clinical settings, persistent presence of biofilms …

Plasmids manipulate bacterial behaviour through translational regulatory crosstalk

CMA Thompson, JPJ Hall, G Chandra, C Martins… - PLoS …, 2023 - journals.plos.org
Beyond their role in horizontal gene transfer, conjugative plasmids commonly encode
homologues of bacterial regulators. Known plasmid regulator homologues have highly …

Multikinase networks: two-component signaling networks integrating multiple stimuli

VI Francis, SL Porter - Annual review of microbiology, 2019 - annualreviews.org
Bacteria depend on two-component systems to detect and respond to threats. Simple
pathways comprise a single sensor kinase (SK) that detects a signal and activates a …

Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa

VI Francis, EM Waters, SE Finton-James, A Gori… - Nature …, 2018 - nature.com
Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-
component systems (TCSs) comprising sensor kinases (SKs) and response regulators …