Cyclosporins are natural or synthetic undecapeptides with a wide range of actual and
potential pharmaceutical applications. Several members of the cyclosporin compound family …

Peptides in general hold much promise as a major ingredient in novel supramolecular
assemblies. They may become essential in vaccine design, antimicrobial chemotherapy …

Several cyclic peptides have been reported to have unexpectedly high membrane
permeability. Of these, cyclosporin A is perhaps the most well-known example, particularly in …

The chameleonic behavior of cyclosporin A (CsA) was investigated through conformational
ensembles employing multicanonical molecular dynamics simulations that could sample the …

The present study was designed to investigate the mechanisms involved in blood-brain
barrier (BBB) permeability in bile duct ligation (BDL) model of chronic hepatic …

An atomic view of a main aqueous conformation of cyclosporine A (CycA), an important 11-
amino-acid macrocyclic immunosuppressant, is reported. For decades, it has been a grand …

Cyclosporine A (CyA) holds significant importance as a strategic immunosuppressive drug
for organ transplant patients. In this study, we aimed to produce pure and cost-effective …

Falling outside of Lipinski's rule of five, macrocyclic drugs have accessed unique binding
sites of their target receptors unreachable by traditional small molecules. Cyclosporin (e) A …

Our study reveals the underlying principles governing the passive membrane permeability in
three large N-methylated macrocyclic peptides (N-MeMPs): cyclosporine A (CycA) …

Cyclosporin A (CycA) is a peptide secondary metabolite derived from fungi that plays a
crucial role in transplantation surgery. Cyclic traveling wave ion mobility mass spectrometry …