Six‐membered aromatic nitrogen heterocyclic anti‐tumor agents: Synthesis and applications

J Li, A Gu, XM Nong, S Zhai, ZY Yue… - The Chemical …, 2023 - Wiley Online Library
Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …

NRF2 activation by nitrogen heterocycles: a review

MC Egbujor, P Tucci, UC Onyeije, CN Emeruwa… - Molecules, 2023 - mdpi.com
Several nitrogen heterocyclic analogues have been applied to clinical practice, and about
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …

Pyridylmethyl Radicals for Enantioselective Alkene Hydroalkylation Using “Ene”-Reductases

SG Bender, TK Hyster - ACS Catalysis, 2023 - ACS Publications
Aromatic electron-deficient heterocycles, such as pyridines, are found in many biologically
relevant structures, including those with medicinal applications. Methods for their …

Novel deep eutectic solvent catalysed single-pot open flask synthesis of tetrasubstituted-1H-pyrroles

SL Kumar, S Tabassum, S Govindaraju - Journal of Molecular Liquids, 2024 - Elsevier
Pyrrole and its analogs have garnered immense attention due to their multifaceted biological
significance and versatile applications, ranging from medicinal agents to fundamental …

A Bird's‐Eye View on Deep Eutectic Solvent‐Mediated Multicomponent Synthesis of N‐Heterocycles

L Kumar S, A Servesh, Y Kumar Sriwastav… - …, 2023 - Wiley Online Library
Multicomponent reactions are crucial for operating organic synthesis. In today's world,
chemists concentrate on greener methodologies that cater to rising environmental concerns …

Synergistic fabrication, characterization, and prospective optoelectronic applications of DES grafted activated charcoal dispersed PVA films

S Lokesh Kumar, CJ Binish, J Rajprasad… - Polymers for …, 2024 - Wiley Online Library
This study investigates the synthesis, analysis, and utility of films comprising deep eutectic
solvent (DES) grafted activated charcoal (AC) within a polyvinyl alcohol (PVA) matrix for …

Recent advances in polyethylene glycol as a dual‐functional agent in heterocycle synthesis: Solvent and catalyst

A Servesh, S Lokesh Kumar… - Polymers for …, 2024 - Wiley Online Library
Reactant solubility, which dictates achievable concentrations, and the stability of reaction
intermediates (excited states), solvents modulate the potential energy landscape and …

Modified eco‐friendly and biodegradable chitosan‐based sustainable semiconducting thin films

S Lokesh Kumar, A Servesh, VR Sunitha… - Polymers for …, 2024 - Wiley Online Library
Semiconducting materials are pivotal in various fields, such as solar cells, LEDs,
photovoltaic cells, etc. A nature‐friendly chitosan is a good film‐forming, water‐soluble …

Transition‐Metal‐Free Synthesis of N‐Heterocyclic Compounds via Multi‐Component Reactions

DJ Boruah, L Borkotoky, UD Newar… - Asian Journal of …, 2023 - Wiley Online Library
Multicomponent reactions (MCRs) have emerged as powerful tools in synthetic chemistry for
the efficient synthesis of diverse molecular scaffolds, particularly nitrogen‐containing …

[HTML][HTML] Mn2 (CO) 10 catalyzed visible-light-promoted synthesis of 1H-pyrazole-4-carboxamides; A sustainable multi-component statergy with antibacterial and …

S Govindaraju, SG Ramaraj, A Servesh… - Journal of …, 2024 - Elsevier
Multicomponent reactions play a pivotal role in synthesizing 1H-pyrazole-4-carboxamides,
underscoring its significance in sustainable organic synthesis. These compounds, valued for …