Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

Conspectus One of the recent hot topics in peptide-related chemical biology research is the
potential of cell-penetrating peptides (CPPs). Owing to their ability to deliver exogenous …

Bioactive macromolecular peptides and oligonucleotides have significant therapeutic
potential. However, due to their size, they have no ability to enter the cytoplasm of cells …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

The development of biotechnological protocols based on cationic surfactants is a modern
trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular …

The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …

Introduction: Macromolecular therapeutics, including enzymes, transcription factors, siRNAs,
peptides and large synthetic molecules, can potentially be used to treat human diseases by …

Neuropeptides are expected as therapeutic drug candidates for central nervous system
(CNS) disorders. Intracerebroventricular (icv) administration of glucagon-like peptide-2 (GLP …