[HTML][HTML] The complement system, aging, and aging-related diseases

R Zheng, Y Zhang, K Zhang, Y Yuan, S Jia… - International Journal of …, 2022 - mdpi.com
The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

Targeting epigenetics: a novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets

P Kodam, R Sai Swaroop, SS Pradhan… - Scientific reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …

Study on the Role of an Erythrocyte Membrane‐Coated Nanotheranostic System in Targeted Immune Regulation of Alzheimer's Disease

Y Su, Y Huang, Q Kou, L Lu, H Jiang, X Li… - Advanced …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in the
elderly population. Despite significant advances in studies of the pathobiology on AD, there …

[HTML][HTML] Innate immunity: a balance between disease and adaption to stress

I Faenza, WL Blalock - Biomolecules, 2022 - mdpi.com
Since first being documented in ancient times, the relation of inflammation with injury and
disease has evolved in complexity and causality. Early observations supported a cause …

The human factor H protein family–an update

N Sandor, AE Schneider, AT Matola… - Frontiers in …, 2024 - frontiersin.org
Complement is an ancient and complex network of the immune system and, as such, it plays
vital physiological roles, but it is also involved in numerous pathological processes. The …

The specific mechanism of TREM2 regulation of synaptic clearance in Alzheimer's disease

Q Qin, M Wang, Y Yin, Y Tang - Frontiers in Immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease. Synaptic dysfunction
is an integral feature of AD pathophysiology and a significant factor in early cognitive …

Neuroprotection of low-molecular-weight galactan obtained from Cantharellus cibarius Fr. against Alzheimer's disease

A Zhou, H Cheng, H Liu, L Li, Z Chen, S Chen… - Carbohydrate …, 2023 - Elsevier
The large molecular weight of polysaccharides limits their absorption and utilization by
organisms, affecting their biological activities. In this study, we purified α-1, 6-galactan from …

Probing Protein Structural Changes in Alzheimer's Disease via Quantitative Cross-linking Mass Spectrometry

Z Zhu, X Zhong, B Wang, H Lu, L Li - Analytical chemistry, 2024 - ACS Publications
Alzheimer's disease (AD) is a progressive neurological disorder featuring abnormal protein
aggregation in the brain, including the pathological hallmarks of amyloid plaques and …

The diverse roles of reactive astrocytes in the pathogenesis of amyotrophic lateral sclerosis

K Yang, Y Liu, M Zhang - Brain Sciences, 2024 - mdpi.com
Astrocytes displaying reactive phenotypes are characterized by their ability to remodel
morphologically, molecularly, and functionally in response to pathological stimuli. This …