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Mechanistic pathways of sex differences in cardiovascular disease
V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2017 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …
The protective effects of estrogen on the cardiovascular system
ME Mendelsohn, RH Karas - New England journal of medicine, 1999 - Mass Medical Soc
The incidence of cardiovascular disease differs significantly between men and women, in
part because of differences in risk factors and hormones. 1 The incidence of atherosclerotic …
part because of differences in risk factors and hormones. 1 The incidence of atherosclerotic …
Nuclear receptors: from molecular mechanisms to therapeutics
Nuclear receptors are classically defined as ligand-activated transcription factors that
regulate key functions in reproduction, development, and physiology. Humans have 48 …
regulate key functions in reproduction, development, and physiology. Humans have 48 …
Physiological and molecular basis of thyroid hormone action
Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …
physiological function of virtually all tissues. TH binds to receptors that are ligand …
Mechanisms of estrogen action
S Nilsson, S Makela, E Treuter… - Physiological …, 2001 - journals.physiology.org
Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …
which estrogens bring about these functions has changed during the past decade. Just as …
The RXR heterodimers and orphan receptors
The nuclear receptor superfamily is comprised of over 150 different proteins that have
evolved to mediate a complex array of extracellular signals into transcriptional responses …
evolved to mediate a complex array of extracellular signals into transcriptional responses …
The coregulator exchange in transcriptional functions of nuclear receptors
Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …
expression in a liganddependent manner. Members of the NR superfamily include receptors …
Nuclear hormone receptors and gene expression
A Aranda, A Pascual - Physiological reviews, 2001 - journals.physiology.org
The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid …
Peroxisome proliferator-activated receptor α (PPARα) plays a key role in the transcriptional
control of genes encoding mitochondrial fatty acid β-oxidation (FAO) enzymes. In this study …
control of genes encoding mitochondrial fatty acid β-oxidation (FAO) enzymes. In this study …
Chromosome-wide map** of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast
cancer. The completion of the human genome has allowed the identification of the …
cancer. The completion of the human genome has allowed the identification of the …