Prolonged skeletal muscle inactivity (eg limb immobilization, bed rest, mechanical
ventilation, spinal cord injury, etc.) results in muscle atrophy that manifests into a decreased …

Numerous health problems including acute critical illness, cancer, diseases associated with
chronic inflammation, and neurological disorders often result in skeletal muscle weakness …

Skeletal muscle is the most abundant tissue in the body and is required for numerous vital
functions, including breathing and locomotion. Notably, deterioration of skeletal muscle …

Background The molecular mechanisms underlying denervated skeletal muscle atrophy
with concomitant muscle mass loss have not been fully elucidated. Therefore, this study …

Muscular weakness and muscle wasting may often be observed in critically ill patients on
intensive care units (ICUs) and may present as failure to wean from mechanical ventilation …

Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients
incapable of adequately ventilating and/or oxygenating due to respiratory or other disease …

While skeletal muscle mass is an established primary outcome related to understanding
cancer cachexia mechanisms, considerable gaps exist in our understanding of muscle …

The diaphragm is the primary muscle of inspiration. Its capacity to respond to the load
imposed by pulmonary disease is a major determining factor both in the onset of ventilatory …

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Background Skeletal muscle atrophy involves and requires widespread changes in skeletal
muscle gene expression and signaling pathway, resulting in excessive loss of muscle mass …