Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C **e, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

[HTML][HTML] Peptide therapeutics from venom: Current status and potential

MW Pennington, A Czerwinski, RS Norton - Bioorganic & medicinal …, 2018 - Elsevier
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …

A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes

RA Pyron, FT Burbrink, JJ Wiens - BMC evolutionary biology, 2013 - Springer
Background The extant squamates (> 9400 known species of lizards and snakes) are one of
the most diverse and conspicuous radiations of terrestrial vertebrates, but no studies have …

Complex cocktails: the evolutionary novelty of venoms

NR Casewell, W Wüster, FJ Vonk, RA Harrison… - Trends in ecology & …, 2013 - cell.com
Venoms have evolved on numerous occasions throughout the animal kingdom. These
'biochemical weapon systems' typically function to facilitate, or protect the producing animal …

Kakusan4 and Aminosan: two programs for comparing nonpartitioned, proportional and separate models for combined molecular phylogenetic analyses of multilocus …

AS Tanabe - Molecular Ecology Resources, 2011 - Wiley Online Library
Proportional and separate models able to apply different combination of substitution rate
matrix (SRM) and among‐site rate variation model (ASRVM) to each locus are frequently …

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

FJ Vonk, NR Casewell, CV Henkel… - Proceedings of the …, 2013 - pnas.org
Snakes are limbless predators, and many species use venom to help overpower relatively
large, agile prey. Snake venoms are complex protein mixtures encoded by several …

Assembling the squamate tree of life: perspectives from the phenotype and the fossil record

JA Gauthier, M Kearney, JA Maisano, O Rieppel… - Bulletin of the Peabody …, 2012 - BioOne
We assembled a dataset of 192 carefully selected species—51 extinct and 141 extant—and
976 apomorphies distributed among 610 phenotypic characters to investigate the phylogeny …

Integrated analyses resolve conflicts over squamate reptile phylogeny and reveal unexpected placements for fossil taxa

TW Reeder, TM Townsend, DG Mulcahy, BP Noonan… - PLOS …, 2015 - journals.plos.org
Squamate reptiles (lizards and snakes) are a pivotal group whose relationships have
become increasingly controversial. Squamates include> 9000 species, making them the …

The biology and evolution of spider venoms

T Lüddecke, V Herzig, BM Von Reumont… - Biological …, 2022 - Wiley Online Library
Spiders are diverse, predatory arthropods that have inhabited Earth for around 400 million
years. They are well known for their complex venom systems that are used to overpower …

The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms

BG Fry, K Roelants, DE Champagne… - Annual review of …, 2009 - annualreviews.org
Throughout evolution, numerous proteins have been convergently recruited into the venoms
of various animals, including centipedes, cephalopods, cone snails, fish, insects (several …