From the first reported role of the transcription factor RUNX2 in osteoblast and chondrocyte
differentiation and migration to its involvement in promigratory/proinvasive behavior of …

Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS
family have emerged as important signalling elements in metazoans. Gab/DOS proteins …

Abstract Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited
due to the paucity of comprehensive mutation data on this rare tumor type. To better …

Background Acral melanoma is a rare type of melanoma that affects world populations
irrespective of skin color and has worse survival than other cutaneous melanomas. It has …

Oncogenic alterations to DNA are not transforming in all cellular contexts,. This may be due
to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic …

Adaptor or scaffolding proteins mediate protein–protein interactions that drive the formation
of protein complexes. Grb2-associated binding protein 2 (GAB2) scaffolding protein is an …

Ovarian cancer, the most deadly gynecologic malignancy, is often diagnosed late and at the
advanced stage when the cancer cells have already migrated and invaded into other tissues …

ABSTRACT HVEM (Herpes Virus Entry Mediator) engagement of BTLA (B and T
Lymphocyte Attenuator) triggers inhibitory signals in T cells and could play a role in evading …

Melanoma is an aggressive disease with few standard treatment options. The conventional
classification system for this disease is based on histological growth patterns, with division …

The docking proteins of the Grb-associated binder (Gab) family transduce cellular signals
between receptors and intracellular downstream effectors, and provide a platform for protein …