Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

Adenoviral vectors (AdVs) have attracted much attention in the fields of vaccine
development and treatment for diseases such as genetic disorders and cancer. In this …

Recombinant adenoviruses are among the most promising tools for vaccine antigen
delivery. Recently, the development of new vectors has focused on serotypes to which the …

The insides of cells can be viewed as a treasure trove of targets for therapeutic intervention
of diseases or as deposits for contrasting agents. Increasingly the molecules that need to be …

The cellular internalization (infection of cells) of adenovirus 5 (Ad5) is mediated by the initial
attachment of the globular knob domain of the capsid fiber protein to the cell surface …

Cell-penetrating peptides (CPPs) can cross cellular membranes in a non-toxic fashion,
improving the intracellular delivery of various molecular cargos such as nanoparticles, small …

Endovenously administered oncolytic viruses extravasate and penetrate poorly into tumors.
iRGD is a cyclic peptide that enhances tumor penetration when conjugated or …

Viral particles (VPs) have evolved so as to efficiently enter target cells and to deliver their
genetic material. The current state of knowledge allows us to use VPs in the field of …

Objective Melittin, a cell-penetrating peptide, improves the efficiency of many non-viral gene
delivery vectors, yet its application in viral vectors has not been well studied. The non …

Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene
delivery vectors in life sciences. However, Ad5 is dependent on expression of the …