An Overview of the Factors Involved in Biofilm Production by the Enterococcus Genus

P Șchiopu, DA Toc, IA Colosi, C Costache… - International Journal of …, 2023 - mdpi.com
Enterococcus species are known for their ability to form biofilms, which contributes to their
survival in extreme environments and involvement in persistent bacterial infections …

A comprehensive review on genomics, systems biology and structural biology approaches for combating antimicrobial resistance in ESKAPE pathogens …

P Priyamvada, R Debroy, A Anbarasu… - World Journal of …, 2022 - Springer
In recent decades, antimicrobial resistance has been augmented as a global concern to
public health owing to the global spread of multidrug-resistant strains from different ESKAPE …

Deep learning and structure-based virtual screening for drug discovery against NEK7: a novel target for the treatment of cancer

M Aziz, SA Ejaz, S Zargar, N Akhtar, AT Aborode… - Molecules, 2022 - mdpi.com
NIMA-related kinase7 (NEK7) plays a multifunctional role in cell division and NLRP3
inflammasone activation. A typical expression or any mutation in the genetic makeup of …

[HTML][HTML] Integrated network pharmacology and in-silico approaches to decipher the pharmacological mechanism of Selaginella tamariscina in the treatment of non …

S Kumar, F Abbas, I Ali, MK Gupta, S Kumar, M Garg… - Phytomedicine …, 2023 - Elsevier
Background and purpose Non-small cell lung cancer (NSCLC) is a major pathological type
of lung cancer and accounts for more than 80% of all cases. In healthcare management, it is …

Computational investigation of 1, 3, 4 oxadiazole derivatives as lead inhibitors of VEGFR 2 in comparison with EGFR: Density functional theory, molecular docking and …

MS Bilal, SA Ejaz, S Zargar, N Akhtar, TA Wani, N Riaz… - Biomolecules, 2022 - mdpi.com
Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth
and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the …

Aldose reductase inhibitory and antiglycation properties of phytoconstituents of Cichorium intybus: Potential therapeutic role in diabetic retinopathy

S Ahmad, MFA Ahmad, S Alouffi, S Khan… - International Journal of …, 2024 - Elsevier
Diabetic vascular complication including diabetic retinopathy is a major morbidity in Saudia
Arabia. The polyol pathway aka aldose reductase (AR) pathway has gained significant …

In-silico identification of small molecule benzofuran-1, 2, 3-triazole hybrids as potential inhibitors targeting EGFR in lung cancer via ligand-based pharmacophore …

S Kumar, I Ali, F Abbas, N Khan, MK Gupta… - In Silico …, 2023 - Springer
Lung cancer is one of the most common and deadly types of cancer worldwide, and the
epidermal growth factor receptor (EGFR) has emerged as a promising therapeutic target for …

Revisiting the inhibitory potential of protein kinase inhibitors against NEK7 protein via comprehensive computational investigations

SA Ejaz, M Aziz, Z Zafar, N Akhtar, HA Ogaly - Scientific Reports, 2023 - nature.com
The NEK7 protein is required for spindle formation, cell division, and the activation of the
NLRP3 inflammasome receptor. The aberrant expression of NEK7 has been implicated to …

Enterococcus raffinosus, Enterococcus durans and Enterococcus avium Isolated from a Tertiary Care Hospital in Romania—Retrospective Study and Brief Review

DA Toc, SL Pandrea, A Botan, RM Mihaila… - Biology, 2022 - mdpi.com
Simple Summary Enterococcus faecium and Enterococcus faecalis are the most common
species of Enterococcus spp. genus involved in human pathology. They are known for their …

In-silico design, pharmacophore-based screening, and molecular docking studies reveal that benzimidazole-1,2,3-triazole hybrids as novel EGFR inhibitors targeting …

S Kumar, I Ali, F Abbas, A Rana, S Pandey… - Journal of …, 2024 - Taylor & Francis
Lung cancer is a complex and heterogeneous disease, which has been associated with
various molecular alterations, including the overexpression and mutations of the epidermal …