Estrogen is a steroid hormone that has critical roles in reproductive development, bone
homeostasis, cardiovascular remodeling and brain functions. However, estrogen also …

A myriad of physiological processes in mammals are influenced by estrogens and the
estrogen receptors (ERs), ERα and ERβ. As we reviewed previously, given the widespread …

Sex steroids have been widely described to be associated with a number of human
diseases, including hormone-dependent tumors. Several studies have been concerned …

OBJECTIVE: To determine whether hormonal therapies have efficacy in patients with
recurrent low-grade serous carcinoma of the ovary or peritoneum. METHODS: We searched …

Ovarian cancer (OC) remains the leading cause of mortality due to gynecological
malignancies. Epidemiological studies have demonstrated that steroid hormones released …

Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium. Compared
with normal colon tissue, ERβ expression is reduced in colorectal cancer. Our hypothesis is …

The involvement of estrogen and its receptors in the development of cancer has been known
for years. However, the exact mechanism responsible is far from clear. The estrogen …

Ovarian cancer is still the deadliest of all gynecologic malignancies in women worldwide.
This is attributed to two main features of these tumors, namely,(i) a diagnosis at an advanced …

Tumorigenesis is a multistep process involving dysregulated cell growth and metastasis.
Considerable evidence implicates a mitogenic action of estrogen in early ovarian …

Background Ovarian cancer is the most lethal gynaecological malignancy. Chemotherapy is
the main stay of treatment for metastatic disease, with modest response rates but significant …