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[HTML][HTML] Novel agents for the pharmacological treatment of alcohol use disorder
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
EASL Clinical Practice Guidelines: Management of alcohol-related liver disease
The harmful use of alcohol has been estimated to cause approximately 3.3 million deaths
every year, corresponding to nearly 6% of all deaths globally. Therefore, the effective …
every year, corresponding to nearly 6% of all deaths globally. Therefore, the effective …
Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: a multicentre, randomised, double-blind controlled trial
Previous randomised placebo-controlled trials with low-to-medium doses of baclofen (30–60
mg) showed inconsistent results, but case studies suggested a dose-response effect and …
mg) showed inconsistent results, but case studies suggested a dose-response effect and …
Precision medicine in alcohol dependence: a controlled trial testing pharmacotherapy response among reward and relief drinking phenotypes
Randomized trials of medications for alcohol dependence (AD) often report no differences
between active medications. Few studies in AD have tested hypotheses regarding which …
between active medications. Few studies in AD have tested hypotheses regarding which …
Long-term efficacy, tolerability and safety of nalmefene as-needed in patients with alcohol dependence: A 1-year, randomised controlled study
W van den Brink, P Sørensen, L Torup… - Journal of …, 2014 - journals.sagepub.com
This study evaluated the long-term efficacy and safety of nalmefene treatment in reducing
alcohol consumption. We randomised (1: 3) 675 alcohol-dependent patients≥ 18 years of …
alcohol consumption. We randomised (1: 3) 675 alcohol-dependent patients≥ 18 years of …
Pharmacotherapy for alcohol dependence: the 2015 recommendations of the French Alcohol Society, issued in partnership with the European Federation of Addiction …
Summary Background The latest French good practice recommendations (GPR s) for the
screening, prevention, and treatment of alcohol misuse were recently published in …
screening, prevention, and treatment of alcohol misuse were recently published in …
Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy
Nalmefene, a mu-and delta-opioid receptor (MOR, DOR) antagonist and a partial kappa-
opioid receptor (KOR) agonist, is approved in the European Union and other countries for …
opioid receptor (KOR) agonist, is approved in the European Union and other countries for …
Risks and benefits of nalmefene in the treatment of adult alcohol dependence: a systematic literature review and meta-analysis of published and unpublished double …
C Palpacuer, B Laviolle, R Boussageon… - PLoS …, 2015 - journals.plos.org
Background Nalmefene is a recent option in alcohol dependence treatment. Its approval
was controversial. We conducted a systematic review and meta-analysis of the aggregated …
was controversial. We conducted a systematic review and meta-analysis of the aggregated …
[ספר][B] The myth of the moral brain: The limits of moral enhancement
H Wiseman - 2016 - books.google.com
An argument that moral functioning is immeasurably complex, mediated by biology but not
determined by it. Throughout history, humanity has been seen as being in need of …
determined by it. Throughout history, humanity has been seen as being in need of …
Pharmacotherapy of alcoholism–an update on approved and off-label medications
M Soyka, CA Müller - Expert opinion on pharmacotherapy, 2017 - Taylor & Francis
Introduction: Only a few medications are available for the treatment of alcohol use disorders
(AUDs). Areas covered: This paper discusses approved AUD medications, including the …
(AUDs). Areas covered: This paper discusses approved AUD medications, including the …