Immunobiology and pathogenesis of viral hepatitis
LG Guidotti, FV Chisari - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …
Adaptive immune responses in acute and chronic hepatitis C virus infection
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …
cause of human illness and death globally. Recent studies have yielded important insights …
Evasion of intracellular host defence by hepatitis C virus
M Gale Jr, EM Foy - Nature, 2005 - nature.com
Viral infection of mammalian cells rapidly triggers intracellular signalling events leading to
interferon α/β production and a cellular antiviral state. This 'host response'is our first line of …
interferon α/β production and a cellular antiviral state. This 'host response'is our first line of …
Stealth and cunning: hepatitis B and hepatitis C viruses
SF Wieland, FV Chisari - Journal of virology, 2005 - Am Soc Microbiol
The hepatitis B virus (HBV) and hepatitis C virus (HCV) are noncytopathic, hepatotropic
members of the hepadnavirus (HBV) and ffavivirus (HCV) families that cause acute and …
members of the hepadnavirus (HBV) and ffavivirus (HCV) families that cause acute and …
PD-L1 is induced in hepatocytes by viral infection and by interferon-α and-γ and mediates T cell apoptosis
M Mühlbauer, M Fleck, C Schütz, T Weiss, M Froh… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: B7-H1 (PD-L1) is a B7-family member that binds to programmed
death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in …
death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in …
Platelets mediate cytotoxic T lymphocyte–induced liver damage
We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic
T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis …
T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis …
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence
J Schulze zur Wiesch, D Ciuffreda… - Journal of Experimental …, 2012 - rupress.org
Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …
Flying under the radar: the immunobiology of hepatitis C
LB Dustin, CM Rice - Annu. Rev. Immunol., 2007 - annualreviews.org
The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent
infection in more than two-thirds of those who contract it. Its success is related to its abilities …
infection in more than two-thirds of those who contract it. Its success is related to its abilities …
Disease progression in chronic hepatitis C: modifiable and nonmodifiable factors
SB Missiha, M Ostrowski, EJ Heathcote - Gastroenterology, 2008 - Elsevier
The hepatic complications of chronic hepatitis C (CHC) usually occur only after progression
to cirrhosis has taken place. Progression to cirrhosis, however, is extremely variable and …
to cirrhosis has taken place. Progression to cirrhosis, however, is extremely variable and …
IL-10, T cell exhaustion and viral persistence
SD Blackburn, EJ Wherry - Trends in microbiology, 2007 - cell.com
Viral infections can have one of two outcomes: control of viral replication and acute infection
or viral persistence and chronic infection. It is clear that both pathogen and host …
or viral persistence and chronic infection. It is clear that both pathogen and host …