Genetically encoded indicators of neuronal activity
Experimental efforts to understand how the brain represents, stores and processes
information require high-fidelity recordings of multiple different forms of neural activity within …
information require high-fidelity recordings of multiple different forms of neural activity within …
Imaging calcium in neurons
Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
[HTML][HTML] Non-canonical odor coding in the mosquito
Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including
dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor …
dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor …
Mosquito brains encode unique features of human odour to drive host seeking
A globally invasive form of the mosquito Aedes aegypti specializes in biting humans, making
it an efficient disease vector. Host-seeking female mosquitoes strongly prefer human odour …
it an efficient disease vector. Host-seeking female mosquitoes strongly prefer human odour …
Cryo-EM structure of the insect olfactory receptor Orco
The olfactory system must recognize and discriminate amongst an enormous variety of
chemicals in the environment. To contend with such diversity, insects have evolved a family …
chemicals in the environment. To contend with such diversity, insects have evolved a family …
A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies
The neurotransmitter acetylcholine (ACh) regulates a diverse array of physiological
processes throughout the body. Despite its importance, cholinergic transmission in the …
processes throughout the body. Despite its importance, cholinergic transmission in the …
A nutrient-specific gut hormone arbitrates between courtship and feeding
Animals must set behavioural priority in a context-dependent manner and switch from one
behaviour to another at the appropriate moment,–. Here we probe the molecular and …
behaviour to another at the appropriate moment,–. Here we probe the molecular and …
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Genetically encoded calcium indicators (GECIs) can be used to image activity in defined
neuronal populations. However, current GECIs produce inferior signals compared to …
neuronal populations. However, current GECIs produce inferior signals compared to …
Deep tissue two-photon microscopy
With few exceptions biological tissues strongly scatter light, making high-resolution deep
imaging impossible for traditional—including confocal—fluorescence microscopy. Nonlinear …
imaging impossible for traditional—including confocal—fluorescence microscopy. Nonlinear …
Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
Fruit flies are attracted by a diversity of odors that signal the presence of food, potential
mates, or attractive egg-laying sites. Most Drosophila olfactory neurons express two types of …
mates, or attractive egg-laying sites. Most Drosophila olfactory neurons express two types of …