Glioblastoma (GBM) is one of the deadliest types of cancer and highly refractory to
chemoradiation and immunotherapy. One of the main reasons for this resistance to therapy …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumour in humans and has a very poor prognosis. The existing treatments have had limited …

Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …

Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind
the transactivation domain of p53 and downregulate its ability to activate transcription. In …

Glioblastoma is the most frequent and most malignant human brain tumor. The prognosis
remains very poor, with most patients dying within 1 year after diagnosis. Primary and …

The p53 tumor suppressor gene is inactivated in human tumors by several distinct
mechanisms. The best characterized inactivation mechanisms are:(i) gene mutation;(ii) p53 …

Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

Here we report the isolation of a cDNA encoding a new p53‐associating protein. This new
protein has been called MDMX on the basis of its structural similarity to MDM2, which is …