The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

We have studied the role of phosphatidylinositol 3-OH kinase (PI3K)-Akt signaling in
transforming growth factor β (TGFβ)-mediated epithelial to mesenchymal transition (EMT). In …

GTPases and lipid kinases regulate membrane traffic along the endocytic pathway by
mechanisms that are not completely understood,,,. Fusion between early endosomes …

Recent studies indicate that phosphatidylinositol 3‐kinase is essential in the regulation of
many processes dependent on membrane flow. Autophagy is a complex pathway in which …

Phosphoinositide 3-kinase (PI 3-kinase) has been implicated in growth factor signal
transduction and vesicular membrane traffic. It is thought to mediate the earliest steps …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

* Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse, 01307
Dresden, Germany† European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1 …