Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …

The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …

The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and
to achieve this function it must continually adapt to varying tissue demands. Newly formed …

Sprouting angiogenesis is fundamental for development and contributes to cancer, diabetic
retinopathy, and cardiovascular diseases. Sprouting angiogenesis depends on the invasive …

Background: Hypoxia and consequent production of vascular endothelial growth factor A
(VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA …

Light-sheet fluorescence microscopy (LSFM) combined with tissue clearing has emerged as
a powerful technology in drug discovery. LSFM is applicable to a variety of samples, from …

Microscopic imaging is essential and the most popular method for in situ monitoring and
evaluating the outcome of various organ-on-a-chip (OOC) platforms, including the number …

Acquired brain injuries due to trauma damage the cortical vasculature, which in turn impairs
blood flow to injured tissues. There are reports of vascular morphological recovery following …

While fluorescence microscopy has proven to be an exceedingly useful tool in bioscience, it
is difficult to offer simultaneous high resolution, fast speed, large volume, and good …

Abstract In three‐dimensional (3D) space, an unbiased and systemic view of human
specimens between structures and functions is required. However, conventional histological …