The prevalence of obesity is increasing in older adults and contributes to age-related
decline. Caloric restriction (CR) alleviates obesity phenotypes and delays the onset of age …

Flourishing recent comparative studies on senescence have revealed an uncovered
diversity across the tree of life of the shapes of the age trajectories of mortality (actuarial …

Dietary protein is a key regulator of reproductive effort in animals, but protein consumption
also tends to accelerate senescence and reduce longevity. Given this protein-mediated …

D-pinitol (DP) has been extensively regarded as the main active component of legumes for
anti-aging. In this study, we intended to explore the anti-aging mechanism of DP, utilizing …

The evolution of aging requires mutations with late-life deleterious effects. Classic theories
assume these mutations either have neutral (mutation accumulation) or beneficial …

Adaptive plasticity in life‐history traits is often critical to maximize fitness in the face of
environmental heterogeneity. For example, many organisms respond to a threat to their …

Moderate dietary restriction often prolongs life in laboratory animals, and this response has
been interpreted as an adaptive strategy that promotes survival during famine. However …

Fasting increases lifespan in invertebrates, improves biomarkers of health in vertebrates and
is increasingly proposed as a promising route to improve human health. Nevertheless, little …

Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of
species. However, how late in life application of caloric restriction can extend fly life is not …

Abstract Reduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and
there is a growing interest in its role in regulating immune function. Whilst rIIS can improve …