Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

Cancerous lesions promote tumor growth, motility, invasion, and angiogenesis via
oncogene-driven immunosuppressive leukocyte infiltrates, mainly myeloid-derived …

An increasing body of evidence emphasizes the role of tissue-resident memory T cells (T
RM) in the defense against recurring pathogens and malignant neoplasms. However, little is …

Although naked antigen-encoding RNA has entered clinical testing, basic knowledge on
how to apply this promising novel vaccine format is still pending. By comparing different …

DNA vaccination has suddenly become a favoured strategy for inducing immunity. The
molecular precision offered by gene-based vaccines, together with the facility to include …

Recent work has demonstrated that following the clearance of infection a stable population
of memory T cells remains present in peripheral organs and contributes to the control of …

DNA vaccines have many potential benefits but have failed to generate robust immune
responses in humans. Recently, methods such as in vivo electroporation have demonstrated …

Major histocompatibility complex (MHC) class I molecules associate with a variety of peptide
ligands during biosynthesis and present these ligands on the cell surface for recognition by …

Gene delivery holds great potential for the treatment of many different diseases. Vaccination
with DNA holds particular promise, and may provide a solution to many technical challenges …

Background Preclinical studies and early clinical trials have shown that targeting cancer
neoantigens is a promising approach towards the development of personalized cancer …