Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges

B Chatterjee, B Gorain, K Mohananaidu… - International journal of …, 2019 - Elsevier
Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs
into the CNS at a higher rate and extent than other conventional routes. The mechanism of …

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges

MM Wen, NS El-Salamouni, WM El-Refaie… - Journal of controlled …, 2017 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease with high prevalence in the
rapidly growing elderly population in the develo** world. The currently FDA approved …

Nano-carrier enabled drug delivery systems for nose to brain targeting for the treatment of neurodegenerative disorders

S Md, SK Bhattmisra, F Zeeshan, N Shahzad… - Journal of Drug Delivery …, 2018 - Elsevier
A major hurdle for the treatment of neurodegenerative disorders is the inability of drug
molecules to cross the blood-brain barrier (BBB). Many anti-Parkinson and anti-Alzheimer …

Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation

MH Teaima, MA Eltabeeb, MA El-Nabarawi… - Drug Delivery, 2022 - Taylor & Francis
It was found that propranolol hydrochloride (PNL), which is a beta-blocker used for
hypertension treatment, has a potent spermicidal activity through local anesthetic activity or …

[HTML][HTML] Recent insights into therapeutic potential and nanostructured carrier systems of Centella asiatica: An evidence-based review

K Bansal, H Bhati, M Bajpai - Pharmacological Research-Modern …, 2024 - Elsevier
ABSTRACT Introduction: Centella asiatica (L.) Urb. is an authentic herbal medicine that is
frequently used in Southeast Asian regions and scientific investigations have demonstrated …

Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect

LM Ahmed, KMA Hassanein, FA Mohamed… - Scientific Reports, 2023 - nature.com
Wound healing is one of the most challenging medical circumstances for patients.
Pathogens can infect wounds, resulting in tissue damage, inflammation, and disruption of …

Intranasal nanoparticulate systems as alternative route of drug delivery

A Alshweiat, R Ambrus, II Csóka - Current medicinal chemistry, 2019 - ingentaconnect.com
There is always a need for alternative and efficient methods of drug delivery. The nasal
cavity can be considered as a non-invasive and efficient route of administration. It has been …

Nanoemulsions: summary of a decade of research and recent advances

VP Chavda, PC Balar, R Bezbaruah, DA Vaghela… - …, 2024 - Taylor & Francis
Nanoemulsions consist of a combination of several components such as oil, water,
emulsifiers, surfactants and cosurfactants. Various techniques for producing nanoemulsions …

[HTML][HTML] Synthesis and characterization of chitosan-decorated nanoemulsion gel of 5-fluorouracil for topical delivery

A Nawaz, MS Latif, MA Alnuwaiser, S Ullah, M Iqbal… - Gels, 2022 - mdpi.com
(1) Background: The present study aimed to prepare chitosan-coated nanoemulsion gel
containing 5-fluorouracil for enhanced topical delivery.(2) Methods: To formulate the …

Olive oil based methotrexate loaded topical nanoemulsion gel for the treatment of imiquimod induced psoriasis-like skin inflammation in an animal model

SA Rashid, S Bashir, F Naseem, A Farid, IA Rather… - Biology, 2021 - mdpi.com
Simple Summary Psoriasis, being chronic inflammatory illness, provoked by genetic and
environmental factors is linked to several other life-threatening diseases. Methotrexate is …