Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …

Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …

In native states, animal cells of many types are supported by a fibrous network that forms the
main structural component of the ECM. Mechanical interactions between cells and the 3D …

Cells generate mechanical forces (traction forces, TFs) while interacting with the
extracellular matrix or neighbouring cells. Forces are generated by both cells and …

Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment,
largely guided by external chemical and mechanical cues. Our current understanding of …

Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

Traction force microscopy (TFM) has emerged as a versatile technique for the measurement
of single-cell-generated forces. TFM has gained wide use among mechanobiology …

Extracellular biophysical cues have a profound influence on a wide range of cell behaviors,
including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal …

With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …