Peptide grafting strategies before and after electrospinning of nanofibers

R Bucci, F Vaghi, E Erba, A Romanelli, ML Gelmi… - Acta Biomaterialia, 2021 - Elsevier
Nanofiber films produced by electrospinning currently provide a promising platform for
different applications. Although nonfunctionalized nanofiber films from natural or synthetic …

Density functional theory calculations: A useful tool to investigate mechanisms of 1, 3-dipolar cycloaddition reactions

MA Chiacchio, L Legnani - International Journal of Molecular Sciences, 2024 - mdpi.com
The present review contains a representative sampling of mechanistic studies, which have
appeared in the literature in the last 5 years, on 1, 3-dipolar cycloaddition reactions, using …

[HTML][HTML] Peptide-based electrospun fibers: Current status and emerging developments

R Bucci, E Georgilis, AM Bittner, ML Gelmi, F Clerici - Nanomaterials, 2021 - mdpi.com
Electrospinning is a well-known, straightforward, and versatile technique, widely used for the
preparation of fibers by electrifying a polymer solution. However, a high molecular weight is …

Smart Electrospun nanofibers from short peptidomimetics based on pyrrolo-pyrazole scaffold

E Chiesa, F Clerici, R Bucci, F Anastasi… - …, 2024 - ACS Publications
We prepared a small library of short peptidomimetics based on 3-pyrrolo-pyrazole
carboxylate, a non-coded γ-amino acid, and glycine or alanine. The robust and eco-friendly …

From glucose to enantiopure morpholino β-amino acid: A new tool for stabilizing γ-turns in peptides

R Bucci, A Contini, F Clerici, S Pellegrino… - Organic Chemistry …, 2019 - pubs.rsc.org
A new cyclic enantiopure β-amino acid, named β-Morph, containing the morpholino ring,
was obtained in gram scale starting from an α-D-glucopyranose enantiopure material …

Non-natural 3-Arylmorpholino-β-amino Acid as a PPII Helix Inducer

F Vaghi, R Bucci, F Clerici, A Contini, ML Gelmi - Organic Letters, 2020 - ACS Publications
A new non-natural β-amino acid, named 3-Ar-β-Morph, was designed and synthesized via a
regio-and diastereoselective Pd-catalyzed C (sp3) H-arylation of the corresponding 2 S, 6 S …

Copper (II)‐Catalyzed Aminohalogenation of Alkynyl Carbamates

S Giofrè, C Loro, L Molteni, C Castellano… - European Journal of …, 2021 - Wiley Online Library
A useful aminohalogenation reaction for the cyclization of O‐alkynyl carbamates under
copper catalysis has been developed. N‐Halosuccinimides have been used as a halogen …

Bicyclic pyrrolidine-isoxazoline γ amino acid: A constrained scaffold for stabilizing α-turn conformation in isolated peptides

F Oliva, R Bucci, L Tamborini, S Pieraccini… - Frontiers in …, 2019 - frontiersin.org
Unnatural amino acids have tremendously expanded the folding possibilities of peptides
and peptide mimics. While α, α-disubstituted and β-amino acids are widely studied, γ …

Alternative strategy to obtain artificial imine reductase by exploiting vancomycin/D-ala-D-ala interactions with an iridium metal complex

G Facchetti, R Bucci, M Fusè, E Erba… - Inorganic …, 2021 - ACS Publications
Based on the supramolecular interaction between vancomycin (Van), an antibiotic
glycopeptide, and D-Ala-D-Ala (DADA) dipeptides, a novel class of artificial metalloenzymes …

On-resin multicomponent 1, 3-dipolar cycloaddition of cyclopentanone–proline enamines and sulfonylazides as an efficient tool for the synthesis of amidino …

R Bucci, F Dapiaggi, H Macut, S Pieraccini, M Sironi… - Amino Acids, 2020 - Springer
Depsipeptides are biologically active peptide derivatives that possess a high therapeutic
interest. The development of depsipeptide mimics characterized by a chemical diversity …