For the brain to operate normally and to develop with structural integrity in addition to
neuronal function, blood-brain barrier present in brain capillaries serves as a vital barrier …

The blood–brain barrier (BBB) is an essential component of the neurovascular unit that
controls the exchanges of various biological substances between the blood and the brain …

Aims/hypothesis Microvascular endothelial hyperpermeability, mainly caused by claudin-5
deficiency, is the initial pathological change that occurs in diabetes-associated …

Zika virus (ZIKV) is a neurotropic virus that causes microcephaly in newborns and Guillain-
Barré syndrome (GBS) in adults. ZIKV is known to transmigrate through the blood–brain …

Vascular and mitochondrial dysfunction are well-established consequences of spinal cord
injury (SCI). Evidence suggests mitigating these dysfunctions may be an effective approach …

Abstract Background Mammalian Claudin-5 is the main endothelial tight junction component
maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and-3 seal the …

Recombinant tissue-type plasminogen activator (rt-PA), the primary drug for acute ischemic
stroke (IS), has a narrow therapeutic window and carries a potential risk of hemorrhagic …

Paritaprevir is a potent inhibitor of the NS3/4A protease used to treat chronic hepatitis C
virus infection. However, its therapeutic effect on acute lung injury (ALI) remains to be …

Purpose: To investigate the therapeutic benefits of Hydroxysafflor yellow A (HSYA) on blood-
brain barrier (BBB) vulnerability after traumatic brain injury (TBI) and identify its potential …

The neurovascular unit, comprised of vascular cell types that collectively regulate cerebral
blood flow to meet the needs of coupled neurons, is paramount for the proper function of the …