Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …

Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Human brain imaging has identified structural changes in gray and white matter that occur
with learning. However, ascribing imaging measures to underlying cellular and molecular …

Animal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-
like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical
region for recall and recognition memory. In a mechanistic proof-of-concept intervention over …

Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …