Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
Therapeutic potential of NAD-boosting molecules: the in vivo evidence
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …
well known for its role in redox reactions. More recently, it has emerged as a signaling …
NAD+ intermediates: the biology and therapeutic potential of NMN and NR
Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …
insights into the pathogenesis of age-associated functional decline and diseases. In …
Slc12a8 is a nicotinamide mononucleotide transporter
A Grozio, KF Mills, J Yoshino, S Bruzzone, G Sociali… - Nature …, 2019 - nature.com
Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of nicotinamide adenine
dinucleotide (NAD+) known to promote cellular NAD+ production and counteract age …
dinucleotide (NAD+) known to promote cellular NAD+ production and counteract age …
NAD+ Homeostasis and NAD+-Consuming Enzymes: Implications for Vascular Health
R Campagna, A Vignini - Antioxidants, 2023 - mdpi.com
Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …
Implications of altered NAD metabolism in metabolic disorders
K Okabe, K Yaku, K Tobe, T Nakagawa - Journal of biomedical science, 2019 - Springer
Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in
various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative …
various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative …
Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women
Y Fukamizu, Y Uchida, A Shigekawa, T Sato… - Scientific reports, 2022 - nature.com
A decrease in the intracellular level of nicotinamide adenine dinucleotide (NAD+), an
essential coenzyme for metabolic activity, causes various age-related diseases and …
essential coenzyme for metabolic activity, causes various age-related diseases and …
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
N Braidy, Y Liu - Experimental Gerontology, 2020 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is
present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of …
present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of …
Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases
K Hikosaka, K Yaku, K Okabe… - Nutritional …, 2021 - Taylor & Francis
Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that mediates various
redox reactions. Particularly, mitochondrial NAD plays a critical role in energy production …
redox reactions. Particularly, mitochondrial NAD plays a critical role in energy production …
Age-Dependent Decline of NAD+—Universal Truth or Confounded Consensus?
Nicotinamide adenine dinucleotide (NAD+) is an essential molecule involved in various
metabolic reactions, acting as an electron donor in the electron transport chain and as a co …
metabolic reactions, acting as an electron donor in the electron transport chain and as a co …