Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

The unprecedented advances in molecular biology during the last two decades have
resulted in a dramatic increase in knowledge about gene structure and function, an …

BACKGROUND: L-type calcium channel (LTCC) mutations have been associated with
Brugada syndrome (BrS), short QT (SQT) syndrome, and Timothy syndrome (LQT8). Little is …

Background Sudden unexpected death in epilepsy (SUDEP) is the leading cause of
epilepsy‐related death. SUDEP shares many features with sudden cardiac death and …

Background—The Brugada syndrome, an inherited syndrome associated with a high
incidence of sudden cardiac arrest, has been linked to mutations in 4 different genes …

The content of this article derives from a Health and Environmental Sciences Institute (HESI)
consortium with a focus to improve cardiac safety during drug development. A detailed …

Epidemiologic studies clearly document the public health burden of sudden unexpected
death in epilepsy (SUDEP). Clinical and experimental studies have uncovered dynamic …

Sudden unexpected death in epilepsy (SUDEP) is the most frequent epilepsy‐related cause
of death and is characterized by an absence of any identifiable cause of death at post …

Previous studies suggest native cardiac I Kr channels are composed of alpha subunits
encoded solely by the 1a transcript of the ERG1 gene. Using isoform-specific ERG1 …

The human ether-à-go-go-related gene (HERG) encodes the pore-forming subunit of the
rapidly activating delayed rectifier potassium channel in the heart. We previously showed …