The study of the cortical control of movement experienced a conceptual shift over recent
decades, as the basic currency of understanding shifted from single-neuron tuning towards …

Highlights•Preparatory activity is a neural correlate of motor planning.•Multiple brain areas
cooperate to maintain preparatory activity.•Preparatory activity sets network activity to an …

Sensory, motor and cognitive operations involve the coordinated action of large neuronal
populations across multiple brain regions in both superficial and deep structures,. Existing …

INTRODUCTION Motivational drives are internal states that can explain why animals
adaptively display distinct behaviors in response to the same external stimulus …

Imaging is used to map activity across populations of neurons. Microscopes with cellular
resolution have small (< 1 millimeter) fields of view and cannot simultaneously image activity …

Neural circuits must perform computations and then selectively output the results to other
circuits. Yet synapses do not change radically at millisecond timescales. A key question then …

When making a subjective choice, the brain must compute a value for each option and
compare those values to make a decision. The orbitofrontal cortex (OFC) is critically involved …

The posterior parietal cortex (PPC) has an important role in many cognitive behaviours;
however, the neural circuit dynamics underlying PPC function are not well understood. Here …

Our ability to move is central to everyday life. Investigating the neural control of movement in
general, and the cortical control of volitional arm movements in particular, has been a major …

One major challenge of neuroscience is identifying structure in seemingly disorganized
neural activity. Different types of structure have different computational implications that can …