A wide array of molecular pathways has been investigated during the past decade in order
to understand the mechanisms by which the practice of physical exercise promotes …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

Physical exercise is well known as a non-pharmacological and holistic therapy believed to
prevent and mitigate numerous neurological conditions and alleviate ageing-related …

Structural and functional alterations to the gut microbiome, referred to as gut dysbiosis, have
emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) …

A high-fat diet (HFD) induces changes in gut microbiota leading to activation of pro-
inflammatory pathways, and obesity, as a consequence of overnutrition, exacerbates …

Numerous studies found intestinal microbiota alterations which are thought to affect the
development of various diseases through the production of gut-derived metabolites …

Obesity is one of the worldwide prevalent disease caused by the imbalance between food
intake and energy expenditure. Over a 100 years of research demonstrate that …