Control of energy homeostasis by the lateral hypothalamic area

MA Rossi - Trends in neurosciences, 2023 - cell.com
The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over
motivated behavior, feeding, and energy balance across species. Recent single-cell …

Neural cell-types and circuits linking thermoregulation and social behavior

JF Rogers, M Vandendoren, JF Prather… - Neuroscience & …, 2024 - Elsevier
Understanding how social and affective behavioral states are controlled by neural circuits is
a fundamental challenge in neurobiology. Despite increasing understanding of central …

Single‐Cell RNA sequencing and spatial transcriptomics reveal pathogenesis of meningeal lymphatic dysfunction after experimental subarachnoid hemorrhage

X Wang, A Zhang, Q Yu, Z Wang, J Wang… - Advanced …, 2023 - Wiley Online Library
Subarachnoid hemorrhage (SAH) is a devastating subtype of stroke with high mortality and
disability rate. Meningeal lymphatic vessels (mLVs) are a newly discovered intracranial fluid …

Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

YH Lee, YB Kim, KS Kim, M Jang, HY Song… - Nature …, 2023 - nature.com
For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking
and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known …

Two ascending thermosensory pathways from the lateral parabrachial nucleus that mediate behavioral and autonomous thermoregulation

T Yahiro, N Kataoka, K Nakamura - Journal of Neuroscience, 2023 - jneurosci.org
Thermoregulatory behavior in homeothermic animals is an innate behavior to defend body
core temperature from environmental thermal challenges in coordination with autonomous …

A parabrachial-hypothalamic parallel circuit governs cold defense in mice

WZ Yang, H **e, X Du, Q Zhou, Y **ao, Z Zhao… - Nature …, 2023 - nature.com
Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the
neural pathways responsible for cold defense regulation are still unclear. Here, we found …

Lateral septum somatostatin neurons are activated by diverse stressors

M An, HK Kim, H Park, K Kim, G Heo… - Experimental …, 2022 - pmc.ncbi.nlm.nih.gov
The lateral septum (LS) is a forebrain structure that has been implicated in a wide range of
behavioral and physiological responses to stress. However, the specific populations of …

An open-source platform for head-fixed operant and consummatory behavior

A Gordon-Fennell, JM Barbakh, MKT Utley, S Singh… - Elife, 2023 - elifesciences.org
Head-fixed behavioral experiments in rodents permit unparalleled experimental control,
precise measurement of behavior, and concurrent modulation and measurement of neural …

Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA

M Sa, ES Yoo, W Koh, MG Park, HJ Jang, YR Yang… - Nature …, 2023 - nature.com
The lateral hypothalamic area (LHA) regulates food intake and energy balance. Although
LHA neurons innervate adipose tissues, the identity of neurons that regulate fat is undefined …

Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding

JS Alvarado, A Lutas, JC Madara, J Isaac, C Lommer… - Neuron, 2024 - cell.com
Brief stimuli can trigger longer-lasting brain states. G-protein-coupled receptors (GPCRs)
could help sustain such states by coupling slow-timescale molecular signals to neuronal …