Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that
dramatically increases mortality and morbidity. The alteration of protein homeostasis is …

Denervation induces skeletal muscle atrophy, accompanied by complex biochemical and
physiological changes, with potentially devastating outcomes even an increased mortality …

Although denervated muscle atrophy is common, the underlying molecular mechanism
remains unelucidated. We have previously found that oxidative stress and inflammatory …

Ubiquitination is an important post-translational modification (PTM) for protein substrates,
whereby ubiquitin is added to proteins through the coordinated activity of activating (E1) …

Sarcopenia induced by muscle aging is associated with negative outcomes in a variety of
diseases. Long non-coding RNAs are a class of RNAs longer than 200 nucleotides with …

Necroptosis, an actively researched form of programmed cell death closely related to the
inflammatory response, is important in a variety of disorders and diseases. However, the …

The abnormal phosphorylation of the τ-protein is a typical early pathological feature of
Alzheimer's disease (AD). The excessive phosphorylation of the τ-protein in the brain …

Background Skeletal muscle atrophy and fibrosis are pathological conditions that contribute
to morbidity in numerous conditions including aging, cachexia, and denervation. Muscle …

Although many long non-coding RNAs (lncRNAs) have been identified in muscle, some of
their physiological functions and regulatory mechanisms remain elusive. Here we report the …