Current pharmacotherapy and multi-target approaches for Alzheimer's disease
SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
Mannich reaction mediated derivatization of chromones and their biological evaluations as putative multipotent ligands for the treatment of Alzheimer's disease
N Kumar, K Jangid, V Kumar, B Devi, T Arora… - RSC Medicinal …, 2024 - pubs.rsc.org
Alzheimer's disease (AD) is a complex neurological disorder and multiple pathways are
associated with its pathology. Currently available single-targeting drugs are found to be …
associated with its pathology. Currently available single-targeting drugs are found to be …
Phenylstyrylpyrimidine derivatives as potential multipotent therapeutics for Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial neurological disorder that affects millions of
people worldwide. Despite extensive research efforts, there are currently no effective …
people worldwide. Despite extensive research efforts, there are currently no effective …
Artificial intelligence assisted identification of potential tau aggregation inhibitors: ligand-and structure-based virtual screening, in silico ADME, and molecular …
Alzheimer's disease (AD) is a severe, growing, multifactorial disorder affecting millions of
people worldwide characterized by cognitive decline and neurodegeneration. The …
people worldwide characterized by cognitive decline and neurodegeneration. The …
Design, synthesis, and biological evaluation of novel chromanone derivatives as multifunctional agents for the treatment of Alzheimer's Disease
Based on a multitarget strategy, a series of novel chromanone–1-benzyl-1, 2, 3, 6-
tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease …
tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease …
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents
Piperazine derivatives have been of great interest to medicinal chemists in the development
of antidepressant drugs due to their distinct molecular and structural features along with their …
of antidepressant drugs due to their distinct molecular and structural features along with their …
Calcium channel blockers' contribution to overcoming Current drug discovery challenges in Alzheimer's disease
PJ Bernard, D Bellili, L Ismaili - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Alzheimer's disease (AD) is a progressive, irreversible, and multifactorial brain
disorder that gradually and insidiously destroys individual's memory, thinking, and other …
disorder that gradually and insidiously destroys individual's memory, thinking, and other …
Design, Synthesis, and Biological Investigation of Quinazoline Derivatives as Multitargeting Therapeutics in Alzheimer's Disease Therapy
An efficient and promising method of treating complex neurodegenerative diseases like
Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of …
Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of …
Virtual screening and molecular dynamics simulation approach for the identification of potential multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial neurological disorder characterized by memory
loss and cognitive impairment. The currently available single-targeting drugs have miserably …
loss and cognitive impairment. The currently available single-targeting drugs have miserably …