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[HTML][HTML] Translation factor accelerating peptide bond formation on the ribosome: EF-P and eIF5A as entropic catalysts and a potential drug targets
V Mudryi, F Peske, M Rodnina - BBA advances, 2023 - Elsevier
Abstract Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary
translation factors that facilitate peptide bond formation when several sequential proline …
translation factors that facilitate peptide bond formation when several sequential proline …
Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology
J Lassak, A Sieber, M Hellwig - Biological Chemistry, 2022 - degruyter.com
Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical
diversity of post-translational modifications. This results in a wide range of possibilities to …
diversity of post-translational modifications. This results in a wide range of possibilities to …
[HTML][HTML] Decrypting the functional design of unmodified translation elongation factor P
Bacteria overcome ribosome stalling by employing translation elongation factor P (EF-P),
which requires post-translational modification (PTM) for its full activity. However, EF-Ps of the …
which requires post-translational modification (PTM) for its full activity. However, EF-Ps of the …
Versatile Dual Reporter to Identify Ribosome Pausing Motifs Alleviated by Translation Elongation Factor P
U Tomasiunaite, T Brewer, K Burdack… - ACS Synthetic …, 2024 - ACS Publications
Protein synthesis is influenced by the chemical and structural properties of the amino acids
incorporated into the polypeptide chain. Motifs containing consecutive prolines can slow the …
incorporated into the polypeptide chain. Motifs containing consecutive prolines can slow the …
Two RmlC homologs catalyze dTDP-4-keto-6-deoxy-d-glucose epimerization in Pseudomonas putida KT2440
F Koller, J Lassak - Scientific Reports, 2021 - nature.com
Abstract l-Rhamnose is an important monosaccharide both as nutrient source and as
building block in prokaryotic glycoproteins and glycolipids. Generation of those composite …
building block in prokaryotic glycoproteins and glycolipids. Generation of those composite …
De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of elongation factor P
CM McDonnell, M Ghanim, JM Southern… - Bioorganic & Medicinal …, 2022 - Elsevier
An investigation into the effect of modified β-lysines on the growth rates of eubacterial cells
is reported. It is shown that the effects observed are due to the post translational modification …
is reported. It is shown that the effects observed are due to the post translational modification …
[PDF][PDF] BBA Advances
V Mudryi, F Peske, M Rodnina - pure.mpg.de
ABSTRACT Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary
translation factors that facilitate peptide bond formation when several sequential proline …
translation factors that facilitate peptide bond formation when several sequential proline …
Translation elongation factor P and its post-translational modification enzyme EpmA
M Pfab - 2020 - edoc.ub.uni-muenchen.de
Protein translation is a non-uniform process, whereby especially proline-containing motifs
lead to ribosome stalling events. Elongation factor P (EF P) rescues the ribosome by …
lead to ribosome stalling events. Elongation factor P (EF P) rescues the ribosome by …