Cancer nanomedicine: progress, challenges and opportunities
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …
application of various nanotechnologies for more effective and safer cancer treatment …
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …
Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
B Weigelin, AT den Boer, E Wagena, K Broen… - Nature …, 2021 - nature.com
Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a
binary,“yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill …
binary,“yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill …
Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-γ and IL-12
Anti-PD-1 immune checkpoint blockers can induce sustained clinical responses in cancer
but how they function in vivo remains incompletely understood. Here, we combined intravital …
but how they function in vivo remains incompletely understood. Here, we combined intravital …
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy
Tumour-associated macrophages are abundant in many cancers, and often display an
immune-suppressive M2-like phenotype that fosters tumour growth and promotes resistance …
immune-suppressive M2-like phenotype that fosters tumour growth and promotes resistance …
In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
Monoclonal antibodies (mAbs) targeting the immune checkpoint anti–programmed cell
death protein 1 (aPD-1) have demonstrated impressive benefits for the treatment of some …
death protein 1 (aPD-1) have demonstrated impressive benefits for the treatment of some …
An overview of nanoparticles commonly used in fluorescent bioimaging
OS Wolfbeis - Chemical Society Reviews, 2015 - pubs.rsc.org
This article gives an overview of the various kinds of nanoparticles (NPs) that are widely
used for purposes of fluorescent imaging, mainly of cells and tissues. Following an …
used for purposes of fluorescent imaging, mainly of cells and tissues. Following an …
Copper‐free click chemistry: applications in drug delivery, cell Tracking, and tissue engineering
Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or
high pressure. However, copper‐free click chemistry has been shown to have favorable …
high pressure. However, copper‐free click chemistry has been shown to have favorable …
[HTML][HTML] Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Tumor-associated macrophages (TAM) have attracted attention as they can modulate key
cancer-related activities, yet TAM represent a heterogenous group of cells that remain …
cancer-related activities, yet TAM represent a heterogenous group of cells that remain …
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt (IV) pro-drug
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to
cancers, yet clinical results have been unpredictable owing to limited in vivo understanding …
cancers, yet clinical results have been unpredictable owing to limited in vivo understanding …