The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …

Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

Over the past decade, RAS oncogenic proteins have transitioned from being deemed
undruggable to having two clinically approved drugs, with several more in advanced stages …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to
improving patient outcomes. We identified four histology-independent archetype TMEs in …

Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where
adaptive antitumour cellular and humoral responses can be elaborated. Initially described in …

Tertiary lymphoid structures (TLSs) are associated with enhanced immunity in tumors.
However, their formation and functions in colorectal cancer liver metastasis (CRLM) remain …

Immunotherapy has emerged as a crucial strategy to combat cancer by “reprogramming” a
patient's own immune system. Although immunotherapy is typically reserved for patients with …

Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …

Tumour mutational burden (TMB), defined as the total number of somatic non-synonymous
mutations present within the cancer genome, varies across and within cancer types. A first …