Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult
challenge. The cellular membrane is very effective in its role as a selectively permeable …

Cancer is the second leading cause of death affecting nearly one in two people, and the
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

Abstract Cell-penetrating peptides (CPPs), also known as protein transduction domains, are
a class of diverse peptides with 5‑30 amino acids. CPPs are divided into cationic …

Most toxic agents currently used for chemotherapy show a narrow therapeutic window,
because of their inability to distinguish between healthy and cancer cells. Targeted drug …

Specifically addressing cell surface molecules on cancer cells facilitates targeted cancer
therapies that offer the potential to selectively destroy malignant cells, while sparing healthy …

Peptides containing the asparagine-glycine-arginine (NGR) motif are recognized by
CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in …

Prostate cancer is androgen-dependent in its early stages and androgen deprivation
therapy represents the most effective first-line therapeutic approach. However, after an initial …

Receptors for gonadotropin releasing hormone (GnRH) are highly expressed in various
human cancers including breast, ovarian, endometrial, prostate and colorectal cancer …