Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of
drug development in the costly late stage, it has been widely recognized that drug ADMET …

Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …

The increasing incidence of antibiotic resistance has forced the development of unique
antimicrobials with novel multitargeting mechanisms to combat infectious diseases caused …

New efficient antimicrobial agents are urgently needed to combat invasive multidrug-
resistant pathogens infections. Structurally unique benzenesulfonyl thiazoloimines (BSTIs) …

Aloe emodin-conjugated sulfonyl hydrazones were designed and synthesized as novel type
of antibacterial modulators. Aloe emodin benzenesulfonyl hydrazone 5a (AEBH-5a) was …

Chromone derivatives possess a spectrum of biological activities. Chromone has been
recognized as a privileged structure for new drug invention and development. Substitution …

Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an
indispensable approach of molecular and mechanistic diversity for the discovery of …

The synthesis and biological activity evaluation of benzenesulfonyl hydrazones is quite
frequently encountered in scientific literature. This class of compounds is very interesting …

In trying to develop new anticancer agents, a series of sulfonylhydrazones were
synthesized. All synthesized compounds were checked for identity and purity using …

Comprehensive Summary A type of unique azole‐hybridized acylhydrazonyl aloe emodins
(AAEs) were developed as new antibacterial agents for combating bacterial infections …