Synaptic specificity, recognition molecules, and assembly of neural circuits

JR Sanes, SL Zipursky - Cell, 2020 - cell.com
Develo** neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

Adhesion protein structure, molecular affinities, and principles of cell-cell recognition

B Honig, L Shapiro - Cell, 2020 - cell.com
The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

A genetic, genomic, and computational resource for exploring neural circuit function

FP Davis, A Nern, S Picard, MB Reiser, GM Rubin… - Elife, 2020 - elifesciences.org
The anatomy of many neural circuits is being characterized with increasing resolution, but
their molecular properties remain mostly unknown. Here, we characterize gene expression …

[HTML][HTML] A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

AM Allen, MC Neville, S Birtles, V Croset, CD Treiber… - Elife, 2020 - elifesciences.org
The Drosophila ventral nerve cord (VNC) receives and processes descending signals from
the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory …

The computational capabilities of many-to-many protein interaction networks

HE Klumpe, J Garcia-Ojalvo, MB Elowitz, YE Antebi - Cell systems, 2023 - cell.com
Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

Ig superfamily ligand and receptor pairs expressed in synaptic partners in Drosophila

L Tan, KX Zhang, MY Pecot, S Nagarkar-Jaiswal… - Cell, 2015 - cell.com
Information processing relies on precise patterns of synapses between neurons. The cellular
recognition mechanisms regulating this specificity are poorly understood. In the medulla of …

Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons

SK Jetti, AB Crane, Y Akbergenova… - Neuron, 2023 - cell.com
Although neuronal subtypes display unique synaptic organization and function, the
underlying transcriptional differences that establish these features are poorly understood. To …

Color vision in insects: insights from Drosophila

C Schnaitmann, M Pagni, DF Reiff - Journal of Comparative Physiology A, 2020 - Springer
Color vision is an important sensory capability that enhances the detection of contrast in
retinal images. Monochromatic animals exclusively detect temporal and spatial changes in …

Coordination between stochastic and deterministic specification in the Drosophila visual system

M Courgeon, C Desplan - Science, 2019 - science.org
INTRODUCTION Neuronal fate decisions must be coordinated across brain regions so that
the proper stoichiometry of distinct afferents and their target neurons is established. Many …

Brain connectivity inversely scales with developmental temperature in Drosophila

FR Kiral, SB Dutta, GA Linneweber, S Hilgert, C Poppa… - Cell reports, 2021 - cell.com
Variability of synapse numbers and partners despite identical genes reveals the limits of
genetic determinism. Here, we use developmental temperature as a non-genetic …