Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

With the emerging advances in utilizing nanocarriers for biomedical applications, a
molecular-level understanding of the in vivo fate of nanocarriers is necessary. After …

The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Summary Microglia (MG), the brain-resident macrophages, play major roles in health and
disease via a diversity of cellular states. While embryonic MG display a large heterogeneity …

Wound healing is a tightly regulated process that ensures tissue repair and normal function
following injury. It is modulated by activation of pathways such as the transforming growth …

The natural extracellular matrix, with its heterogeneous structure, provides a stable and
dynamic biophysical framework and biochemical signals to guide cellular behaviors. It is …

The extracellular matrix is a structure composed of many molecules, including fibrillar (types
I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens …

Advances in radiation techniques have enabled the precise delivery of higher doses of
radiotherapy to tumours, while sparing surrounding healthy tissues. Consequently, the …

The skin serves as the body's outermost barrier and is the largest organ, providing protection
not only to the body but also to various internal organs. Owing to continuous exposure to …

N-glycosylation is one of the most common types of protein modifications and it plays a vital
role in normal physiological processes. However, aberrant N-glycan modifications are …